Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.66 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7708488 | 0.82 | PDE10A (0.78) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271479 | 0.81 | PDE10A (0.66) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7703623 | 0.81 | PDE10A (0.84) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8272028 | 0.80 | PDE10A (0.75) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8272706 | 0.80 | PDE10A (0.67) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7711236 | 0.80 | PDE10A (0.87) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271482 | 0.80 | PDE10A (0.71) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL7709755 | 0.79 | PDE10A (0.73) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271910 | 0.79 | PDE10A (0.73) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8271478 | 0.79 | PDE10A (0.63) | PDE10ACYP17A1CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011132051-A2 | TRICYCLE COMPOUNDS AS PHOSPHODIESTERASE-10 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2011-10-27 | — | — | WO | disclosed |