Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 2/20 | 0.62 |
| ▸ | FEN1 | P39748 | 2/20 | 0.62 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.62 |
| ▸ | RAD52 | P43351 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | CLTC | Q00610 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461080 | 0.86 | KMT2A (0.55) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL13495348 | 0.85 | RAD52 (0.60) | RAD52KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7706739 | 0.84 | ERCC1 (0.57) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL28870673 | 0.84 | ERCC1 (0.53) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL7703367 | 0.81 | ERCC1 (0.70) | ERCC1FEN1ERCC4KMT2AKDM4E | |
| SCHEMBL13829160 | 0.81 | ERCC1 (0.49) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL7709925 | 0.80 | ERCC1 (0.55) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL7709551 | 0.79 | ERCC1 (0.50) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL13829105 | 0.79 | ERCC1 (0.50) | ERCC1FEN1ERCC4RAD52KMT2A | |
| SCHEMBL7709769 | 0.78 | ERCC1 (0.53) | ERCC1FEN1ERCC4RAD52KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | claimed |
| US-6362181-B1 | BACTERICIDES; ENZYME INHIBITORS; ANTITUMOR AGENTS | WARNER-LAMBERT COMPANY | 2002-03-26 | — | — | US | disclosed |
| US-6177423-B1 | N-(HYDROXY OR PROTECTED HYDROXY)-BENZO(DE)ISOQUINOLINE-1,3-DIONE DERIVATIVES; BACTERIAL DNA GYRASE AND DNA TOPOISOMERASE INHIBITORS USEFUL FOR ANTIBACTERIAL AGENTS HAVING REDUCED DRUG RESISTANCE AND REDUCED SIDE EFFECTS | WARNER-LAMBERT COMPANY | 2001-01-23 | — | — | US | disclosed |