Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 17/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7710970 | 1.00 | DHODH (0.55) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL7108586 | 0.80 | NPC1 (0.53) | ALDH1A1 | |
| SCHEMBL5914908 | 0.78 | DHODH (0.71) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914906 | 0.78 | MEN1 (0.70) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914892 | 0.78 | DHODH (0.58) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914905 | 0.78 | MEN1 (0.70) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914909 | 0.78 | DHODH (0.71) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914893 | 0.78 | DHODH (0.58) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914915 | 0.77 | DHODH (0.57) | DHODHMEN1ALDH1A1KMT2ACYP1A2 | |
| SCHEMBL5914914 | 0.77 | DHODH (0.57) | DHODHMEN1ALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6365626-B1 | LEFLUNOMIDE METABOLITE ANALOGS FOR TREATING IMPROPER PLATELET AGGREGATION; LEUKEMIA; LYMPHOMAS | PARKER HUGHES INSTITUTE | 2002-04-02 | — | — | US | disclosed |