Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.35 |
| ▸ | FAP | Q12884 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4999724 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL4999549 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL4999554 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL4999728 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL5002825 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL5002820 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL4999828 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL4999832 | 0.84 | GAA (0.55) | GAAMAPTDPP7DPP8DPP9 | |
| SCHEMBL14073993 | 0.83 | GAA (0.61) | GAAMAPTSMYD3HDAC2DPP4 | |
| SCHEMBL4999846 | 0.82 | GAA (0.59) | GAAMAPTSMYD3HDAC2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011143495-A1 | HETEROARYLOXYHETEROCYCLYL COMPOUNDS AS PDE10 INHIBITORS | AMGEN INC. (US) | 2011-11-17 | — | — | WO | disclosed |