Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.86 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784109 | 1.00 | PDE5A (0.86) | PDE5AMEN1KMT2AATM | |
| SCHEMBL7714894 | 1.00 | PDE5A (0.86) | PDE5AMEN1KMT2AATM | |
| SCHEMBL1326138 | 0.94 | PDE5A (0.85) | PDE5A | |
| SCHEMBL1326139 | 0.94 | PDE5A (0.85) | PDE5A | |
| SCHEMBL1326142 | 0.94 | PDE5A (0.85) | PDE5A | |
| SCHEMBL7683504 | 0.93 | PDE5A (0.84) | PDE5AKMT2A | |
| SCHEMBL7683497 | 0.93 | PDE5A (0.84) | PDE5AKMT2A | |
| SCHEMBL7433397 | 0.93 | PDE5A (0.84) | PDE5AKMT2A | |
| SCHEMBL6782139 | 0.93 | PDE5A (0.84) | PDE5A | |
| SCHEMBL6782147 | 0.93 | PDE5A (0.84) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6369059-B1 | INHIBITOR OF CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE SPECIFIC PHOSPHODIESTERASE (CGMP SPECIFIC PDE); CARDIOVASCULAR DISORDERS; PYRAZINO(2',1':6,1)PYRIDO(3,4-B)INDOLE-1,4-DIONES | ICOS CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-6025494-A | CYCLIZATION OF DICARBONYL-SUBSTITUTED PYRIDOINDOLES YIELDS PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2000-02-15 | — | — | US | disclosed |