Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 3/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735827 | 0.92 | PDE4D (0.41) | PRF1PDE4DABCG2PDE4APDE4B | |
| SCHEMBL7714383 | 0.78 | PRF1 (0.41) | PRF1PDE4DPOLQMAPTHSD17B10 | |
| SCHEMBL2594611 | 0.78 | POLQ (0.36) | PRF1POLQTSHR | |
| SCHEMBL2584274 | 0.77 | PRF1 (0.42) | PRF1PDE4DKDM4EPDE4APDE4B | |
| SCHEMBL2591559 | 0.76 | PDE4D (0.41) | PRF1PDE4DKDM4EPDE4APDE4B | |
| SCHEMBL7714155 | 0.76 | PRF1 (0.41) | PRF1PDE4DPOLQMAPTHSD17B10 | |
| SCHEMBL2593335 | 0.76 | PDE4D (0.41) | PRF1PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL2591212 | 0.75 | PRF1 (0.44) | PRF1PDE4DKDM4EPDE4APDE4B | |
| SCHEMBL7716439 | 0.75 | PRF1 (0.43) | PRF1PDE4DPOLQMAPTGAA | |
| SCHEMBL14735876 | 0.75 | PDE4D (0.42) | PRF1PDE4DMAPTKDM4EABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |