Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11524014 | 0.98 | TSHR (0.46) | TSHRPPARDACHE | |
| SCHEMBL6187009 | 0.94 | TSHR (0.50) | TSHRPPARDACHE | |
| SCHEMBL491513 | 0.85 | TSHR (0.54) | TSHRPPARDACHE | |
| SCHEMBL13854206 | 0.85 | TSHR (0.45) | TSHRPPARDACHE | |
| SCHEMBL7268189 | 0.82 | PPARD (0.64) | TSHRPPARD | |
| SCHEMBL11514496 | 0.80 | PPARD (0.61) | TSHRPPARD | |
| SCHEMBL7268183 | 0.80 | PPARD (0.61) | TSHRPPARD | |
| SCHEMBL11323349 | 0.80 | PPARD (0.61) | TSHRPPARD | |
| SCHEMBL14713221 | 0.80 | TSHR (0.48) | TSHRPPARD | |
| SCHEMBL19245610 | 0.80 | PPARD (0.45) | TSHRPPARDACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376512-B1 | FOR TREATING PHYSIOLOGICAL CONDITION IN PATIENT WHEREIN SAID CONDITION IS ASSOCIATED WITH A PHYSIOLOGICALLY DETRIMENTAL LEVELS OF INSULIN, GLUCOSE, FREE FATTY ACIDS, OR TRIGLYCERIDES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-23 | — | — | US | disclosed |
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5059610-A | QUINOLINE DERIVATIVES AND THEIR USE AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-10-22 | — | — | US | disclosed |
| US-4920132-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| US-4151229-A | Process for the manufacture of aminoalkyl-phosponic acid esters | CIBA-GEIGY CORPORATION (US) | 1979-04-24 | — | — | US | disclosed |