Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.37 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.37 |
| ▸ | TACR2 | P21452 | 8/20 | 0.94 |
| ▸ | TACR3 | P29371 | 6/20 | 0.42 |
| ▸ | TACR1 | P25103 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7716777 | 1.00 | TACR2 (0.94) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| SCHEMBL3091194 | 0.97 | TACR2 (1.00) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| SCHEMBL3091190 | 0.97 | TACR2 (1.00) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7744616 | 0.96 | TACR2 (0.97) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL7744615 | 0.96 | TACR2 (0.97) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL7719837 | 0.94 | TACR2 (0.93) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL7719845 | 0.94 | TACR2 (0.93) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL7751878 | 0.94 | TACR2 (0.93) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| Fumaric Acid SCHEMBL7719842 | 0.94 | TACR2 (0.93) | TACR2TACR3TACR1CYP3A4CYP2D6 | |
| SCHEMBL4631279 | 0.89 | TACR2 (0.85) | TACR2TACR3TACR1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6392039-B1 | COUPLING; SALT FORMATION | SANOFI-SYNTHELABO (FR) | 2002-05-21 | — | — | US | disclosed |