Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 12/20 | 0.60 |
| ▸ | EGFR | P00533 | 5/20 | 0.56 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | FLT1 | P17948 | 2/20 | 0.56 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.56 |
| ▸ | STK3 | Q13188 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.56 |
| ▸ | FLT4 | P35916 | 2/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.56 |
| ▸ | LATS1 | O95835 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7716817 | 0.91 | KDR (0.73) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL7716818 | 0.91 | KDR (0.73) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL4409722 | 0.87 | KDR (0.78) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL4409721 | 0.87 | KDR (0.78) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL5370172 | 0.80 | KDR (0.59) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL31726830 | 0.77 | ALK (0.76) | KDRFGFR1PDGFRBAURKAFLT3 | |
| SCHEMBL31726848 | 0.77 | PDGFRB (0.74) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL5376617 | 0.77 | PDGFRB (0.74) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL4405035 | 0.77 | KDR (0.81) | KDRFGFR1PDGFRBEGFRAURKA | |
| SCHEMBL4405036 | 0.77 | KDR (0.81) | KDRFGFR1PDGFRBEGFRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233943-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | Sugen, Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1082305-A4 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN INC (US) | 2001-09-26 | — | — | EP | disclosed |
| WO-2001037820-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | SUGEN, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| EP-1082305-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999061422-A1 | PYRROLE SUBSTITUTED 2-INDOLINONE PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 1999-12-02 | — | — | WO | disclosed |