SCHEMBL7718583

SCHEMBL7718583

SCCCc1cnccn1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.34
HDAC3 O15379 3/20 0.33
HDAC1 Q13547 3/20 0.33
HDAC2 Q92769 3/20 0.33
HDAC6 Q9UBN7 3/20 0.33
HDAC4 P56524 2/20 0.33
HDAC7 Q8WUI4 2/20 0.33
HDAC10 Q969S8 2/20 0.33
HDAC11 Q96DB2 2/20 0.33
HDAC8 Q9BY41 2/20 0.33
HDAC9 Q9UKV0 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HRH1 P35367 5/20 0.33
CYP2D6 P10635 5/20 0.33
KCNH2 Q12809 4/20 0.33
TLR7 Q9NYK1 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL978915 0.86
SCHEMBL28362525 0.86 HSP90AA1 (0.40) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL6685244 0.83 HDAC3 (0.37) HSP90AA1HDAC3HDAC1HDAC2HDAC6
Ethane SCHEMBL29272596 0.83 HRH1 (0.35) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL14835009 0.78 HSP90AA1 (0.34) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL12441745 0.78 HSP90AA1 (0.34) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL6685246 0.78 POLB (0.40) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL6287667 0.78 CYP2A6 (0.47) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL7718580 0.78 HSP90AA1 (0.34) HSP90AA1HDAC3HDAC1HDAC2HDAC6
SCHEMBL4412197 0.78 CYP2D6 (0.43) CYP3A4CYP2C9CYP2C19HRH1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2002087587-A2 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS CELLTECH R & D LIMITED (GB) 2002-11-07 WO disclosed