Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 15/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL446502 | 0.84 | BACE1 (0.47) | NPC1RAB9ASMN1; SMN2KMT2APKM | |
| SCHEMBL10295976 | 0.75 | BACE1 (0.70) | BACE1 | |
| SCHEMBL449002 | 0.67 | BACE1 (0.60) | NPC1RAB9ASMN1; SMN2TP53BACE1 | |
| SCHEMBL446462 | 0.67 | BACE1 (0.56) | BACE1BACE2 | |
| SCHEMBL445972 | 0.64 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL447947 | 0.64 | BACE1 (0.61) | BACE1BACE2 | |
| SCHEMBL4082786 | 0.64 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL2279765 | 0.63 | CA1 (0.62) | NPC1RAB9ASMN1; SMN2KMT2APKM | |
| SCHEMBL448330 | 0.63 | BACE1 (0.68) | BACE1BACE2 | |
| SCHEMBL4077971 | 0.62 | BACE1 (0.67) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123674-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-06 | — | — | WO | disclosed |