SCHEMBL7722374

C[C@@H](O)[C@H]1C(=O)N2C(C(=O)OCc3ccc([N+](=O)[O-])cc3)=C(c3cn4cnc(C(=O)CNC(=O)OCc5ccc([N+](=O)[O-])cc5)c4s3)[C@H](C)[C@H]12

nearest known ligand 0.38

Predicted protein targets (top 7)

	gene	UniProt	supporting neighbours	confidence
▸	PLCG1	P19174	1/20	0.35

▸	ELANE	P08246	4/20	0.32

▸	DPP8	Q6V1X1	1/20	0.32

▸	DPP9	Q86TI2	1/20	0.32

▸	HTR2A	P28223	1/20	0.32

▸	L3MBTL1	Q9Y468	2/20	0.30

▸	HTT	P42858	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7731024	0.95	PLCG1 (0.35)	PLCG1ELANEHTR2AL3MBTL1HTT
SCHEMBL6889515	0.95	PLCG1 (0.32)	PLCG1ELANEDPP8DPP9HTR2A
SCHEMBL7728957	0.92	PLCG1 (0.37)	PLCG1ELANEHTR2AL3MBTL1HTT
SCHEMBL7728180	0.92	PLCG1 (0.32)	PLCG1DPP8DPP9
SCHEMBL7730458	0.91	PLCG1 (0.35)	PLCG1ELANEHTR2AL3MBTL1HTT
SCHEMBL7728647	0.91	ELANE (0.36)	PLCG1ELANEHTR2AL3MBTL1HTT
SCHEMBL7722446	0.91	ELANE (0.36)	PLCG1ELANEHTR2AL3MBTL1HTT
SCHEMBL7731983	0.91	PLCG1 (0.34)	PLCG1ELANEHTR2A
SCHEMBL7631759	0.91	PLCG1 (0.36)	PLCG1ELANEHTR2AL3MBTL1HTT
SCHEMBL7041829	0.91	PLCG1 (0.35)	PLCG1ELANEHTR2AL3MBTL1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6458780-B1	IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND	MEIJI SEIKA KAISHA, LTD. (JP)	2002-10-01	—	—	US	disclosed