Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.67 |
| ▸ | PDE4A | P27815 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | PDE2A | O00408 | 1/20 | 0.58 |
| ▸ | PDE6D | O43924 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | PDE9A | O76083 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PDE6A | P16499 | 1/20 | 0.58 |
| ▸ | PDE6G | P18545 | 1/20 | 0.58 |
| ▸ | PDE6B | P35913 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7721797 | 0.91 | PDE5A (0.69) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7723340 | 0.90 | PDE5A (0.67) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7367432 | 0.89 | PDE5A (0.64) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7718299 | 0.89 | PDE5A (0.66) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9533622 | 0.88 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL7722516 | 0.87 | PDE5A (0.62) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7723475 | 0.86 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7367729 | 0.86 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7723505 | 0.86 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7718066 | 0.86 | PDE5A (0.71) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351058-B1 | PYRIMIDOPYRIMIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| EP-0351058-A1 | Pyrimidopyrimidine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-17 | — | — | EP | claimed |
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0351058-B1 | PYRIMIDOPYRIMIDINE DERIVATIVES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5162316-A | Pyrimido[4,5-d]pyrimidine derivatives for use as bronchodilators | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1992-11-10 | — | — | US | disclosed |
| EP-0351058-A1 | Pyrimidopyrimidine derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-01-17 | — | — | EP | disclosed |