SCHEMBL7722701

SCHEMBL7722701

CCC[C@H]1CC[C@H]([C@H]2CC[C@H](c3ccc(C(=O)O)cc3)CC2)CC1

nearest known ligand 0.69

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.69
ALDH1A1 P00352 2/20 0.66
LMNA P02545 1/20 0.66
MAPT P10636 1/20 0.66
MEN1 O00255 1/20 0.58
MAPK1 P28482 1/20 0.58
KMT2A Q03164 1/20 0.58
ESR2 Q92731 3/20 0.43
HDAC8 Q9BY41 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
HDAC1 Q13547 1/20 0.40
DGAT1 O75907 5/20 0.39
MRGPRX4 Q96LA9 1/20 0.39
HDAC3 O15379 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
TLR4 O00206 1/20 0.39
HAO1 Q9UJM8 1/20 0.38
ESR1 P03372 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7722695 1.00 CYP2C9 (0.69) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL7722697 1.00 CYP2C9 (0.69) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL2770921 0.95 CYP2C9 (0.75) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL3267992 0.95 CYP2C9 (0.75) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL10909905 0.92 CYP2C9 (0.58) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL10909901 0.92 CYP2C9 (0.58) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL10765157 0.92 CYP2C9 (0.58) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL10730169 0.91 CYP2C9 (0.69) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL10730158 0.91 CYP2C9 (0.69) CYP2C9ALDH1A1LMNAMAPTMEN1
SCHEMBL10910850 0.90 CYP2C9 (0.57) CYP2C9ALDH1A1LMNAMAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed
US-4620938-A Hydroterphenyls MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1986-11-04 US disclosed