Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723636 | 1.00 | KMT2A (0.47) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7726274 | 0.92 | KMT2A (0.49) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7726279 | 0.92 | KMT2A (0.49) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7724799 | 0.90 | KMT2A (0.46) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7724804 | 0.90 | KMT2A (0.46) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7723481 | 0.89 | KMT2A (0.47) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7726302 | 0.89 | KMT2A (0.47) | KMT2AMAPTMEN1LMNATP53 | |
| SCHEMBL7723477 | 0.89 | KMT2A (0.47) | KMT2AMAPTMEN1CYP2D6MAPK1 | |
| SCHEMBL7726298 | 0.89 | KMT2A (0.47) | KMT2AMAPTMEN1LMNATP53 | |
| SCHEMBL7723518 | 0.88 | KMT2A (0.44) | KMT2AMAPTMEN1CYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |