Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303296 | 0.80 | TAAR1 (0.52) | TAAR1ADRA1AHTR2ACYP1A2 | |
| SCHEMBL4384909 | 0.77 | TAAR1 (0.55) | TAAR1ADRA1AALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL1437384 | 0.75 | TAAR1 (0.53) | TAAR1ADRA1AALDH1A1CYP1A2 | |
| SCHEMBL20970869 | 0.74 | HTR2A (0.64) | TAAR1HTR2APDE4BHTR7HTR6 | |
| SCHEMBL2587027 | 0.72 | SMN1; SMN2 (0.57) | PDE4BPDE4DALDH1A1CYP1A2 | |
| SCHEMBL34463016 | 0.71 | TAAR1 (0.52) | TAAR1ADRA1AHTR2ACYP1A2 | |
| SCHEMBL1253168 | 0.70 | AOC3 (0.64) | TAAR1ADRA1AHTR2AALDH1A1CYP1A2 | |
| SCHEMBL16011771 | 0.69 | SMN1; SMN2 (0.44) | HTR2APDE4BPDE4DHTR7HTR6 | |
| SCHEMBL2581701 | 0.69 | PDE4D (0.47) | ADRA1AHTR2APDE4BPDE4DHTR7 | |
| Hydrochloric Acid SCHEMBL7366474 | 0.69 | AOC3 (0.62) | TAAR1ADRA1AHTR2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403805-B1 | SUCH AS 1-((1-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL) CYCLOPROPYL)METHYL)-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE FOR ALLERGIES, ATOPIC AND INFLAMMATORY DISEASES WHEREIN ACTIVITY OF PHOSPHODIESTERASE IS ALTERED | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-06-11 | — | — | US | disclosed |