Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | BCR | P11274 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7727582 | 0.89 | HDAC1 (0.47) | HDAC4HDAC1HDAC8HDAC3HDAC7 | |
| SCHEMBL7722336 | 0.87 | SCN9A (0.36) | HDAC4HDAC1TRPV1HDAC8HDAC3 | |
| SCHEMBL7731670 | 0.87 | SCN9A (0.36) | HDAC4HDAC1TRPV1HDAC8HDAC3 | |
| SCHEMBL7722254 | 0.83 | POLB (0.46) | HDAC4HDAC1TRPV1HDAC8HDAC3 | |
| SCHEMBL7722250 | 0.83 | POLB (0.46) | HDAC4HDAC1TRPV1HDAC8HDAC3 | |
| SCHEMBL7731725 | 0.82 | HDAC8 (0.44) | HDAC8POLBABL1BCRMEN1 | |
| SCHEMBL7728662 | 0.82 | DPP4 (0.42) | MEN1KMT2A | |
| SCHEMBL7728992 | 0.82 | POLB (0.56) | HDAC4HDAC1TRPV1HDAC8HDAC3 | |
| SCHEMBL7728996 | 0.82 | POLB (0.56) | HDAC4HDAC1TRPV1HDAC8HDAC3 | |
| SCHEMBL7726525 | 0.82 | POLB (0.56) | HDAC4HDAC1TRPV1HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |