SCHEMBL7730335

SCHEMBL7730335

CCCCc1ccc(C(F)(F)Oc2cc(F)c(F)c(F)c2)cc1

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 2/20 0.36
S1PR3 Q99500 2/20 0.36
HTR2A P28223 1/20 0.36
FAAH O00519 1/20 0.35
CA2 P00918 2/20 0.35
CA1 P00915 1/20 0.35
PLK1 P53350 2/20 0.35
PSEN1 P49768 1/20 0.35
RARB P10826 3/20 0.35
RARA P10276 1/20 0.35
RARG P13631 1/20 0.35
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
HSD17B10 Q99714 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
SKP2 Q13309 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7733197 0.97 S1PR1 (0.37) S1PR1S1PR3HTR2AFAAHCA2
SCHEMBL16257990 0.96 RARB (0.40) S1PR1S1PR3RARBRARARARG
SCHEMBL7731160 0.96 HTR2A (0.41) HTR2AFAAHPLK1RARBRARA
SCHEMBL7735476 0.94 HTR2A (0.44) S1PR1S1PR3HTR2AFAAHPLK1
SCHEMBL7730465 0.94 HTR2A (0.44) S1PR1S1PR3HTR2AFAAHPLK1
SCHEMBL7723125 0.94 HTR2A (0.44) S1PR1S1PR3HTR2AFAAHPLK1
SCHEMBL7730773 0.94 HTR2A (0.44) S1PR1S1PR3HTR2AFAAHPLK1
SCHEMBL7731854 0.94 HTR2A (0.44) S1PR1S1PR3HTR2AFAAHPLK1
SCHEMBL7729708 0.93 HTR2A (0.40) HTR2AFAAHPLK1RARBRARA
SCHEMBL16662430 0.92 RARB (0.45) HTR2AFAAHPLK1RARBRARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180119011-A1 LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE THEREOF JIANGSU HECHENG DISPLAY TECHNOLOGY CO., LTD. (CN) 2018-05-03 US disclosed
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
US-5858270-A Difluorooxymethane derivative and liquid crystal composition CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed