Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 6/20 | 0.58 |
| ▸ | HRH1 | P35367 | 6/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739073 | 1.00 | HRH2 (0.58) | HRH2HRH1HRH3KDM4EKCNH2 | |
| SCHEMBL7732361 | 1.00 | HRH2 (0.58) | HRH2HRH1HRH3KDM4EKCNH2 | |
| SCHEMBL7738905 | 0.94 | HRH2 (0.55) | HRH2HRH1HRH3KDM4ETHRA | |
| SCHEMBL7741808 | 0.87 | HRH2 (0.57) | HRH2HRH1HRH3KDM4EKCNH2 | |
| SCHEMBL13472015 | 0.80 | HRH2 (0.56) | HRH2HRH1HRH3KCNH2THRA | |
| SCHEMBL491570 | 0.79 | HRH3 (0.72) | HRH2HRH1HRH3KDM4E | |
| SCHEMBL15177348 | 0.79 | GAA (0.77) | THRATHRB | |
| SCHEMBL12243177 | 0.79 | GAA (0.77) | THRATHRB | |
| SCHEMBL9000300 | 0.79 | GAA (0.77) | THRATHRB | |
| SCHEMBL7739031 | 0.79 | GAA (0.77) | THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790744-B2 | Cyclic peptide antifungal agents and process for preparation thereof | ELI LILLY AND COMPANY (US) | 2010-09-07 | — | — | US | disclosed |
| US-7790744-B2 | Cyclic peptide antifungal agents and process for preparation thereof | ELI LILLY AND COMPANY (US) | 2010-09-07 | — | — | US | disclosed |
| US-6743777-B1 | TRISPHENYL ACYL DERIVATIVES OF THE ECHINOCANDIN CLASS; CANDIDA ALBICANS; ANTIFUNGAL AND ANTIPARASITIC; CYCLIC HEXAPEPTIDES HAVING UNIQUE SIDE CHAIN ACYL GROUP | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |
| US-6743777-B1 | TRISPHENYL ACYL DERIVATIVES OF THE ECHINOCANDIN CLASS; CANDIDA ALBICANS; ANTIFUNGAL AND ANTIPARASITIC; CYCLIC HEXAPEPTIDES HAVING UNIQUE SIDE CHAIN ACYL GROUP | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |