Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14173202 | 0.97 | HTT (0.53) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL22020008 | 0.97 | HTT (0.53) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL15349 | 0.97 | HTT (0.53) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL20610370 | 0.97 | HTT (0.53) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL11967041 | 0.97 | HTT (0.53) | HTTHIF1AARPOLBMAPT | |
| Methacrylic Acid SCHEMBL14881206 | 0.96 | HTT (0.50) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL3774134 | 0.95 | KMT2A (0.53) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL19479960 | 0.94 | AR (0.54) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL15803522 | 0.94 | HTT (0.50) | HTTHIF1AARPOLBMAPT | |
| SCHEMBL15803542 | 0.94 | HTT (0.50) | HTTHIF1AARPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407148-B1 | ADHESIVE, CURABLE, OR AUTOPOLYMERIZING SEALANT FOR HARD TISSUE; BONDING STRENGTH; SHRINKAGE, POLYMERIZATION AND DISCOLORATION INHIBITION | 3M ESPE AG (DE) | 2002-06-18 | — | — | US | disclosed |