⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788405 | 1.00 | — | — | |
| SCHEMBL22692842 | 1.00 | — | — | |
| SCHEMBL15788434 | 1.00 | — | — | |
| SCHEMBL15894139 | 0.80 | — | — | |
| SCHEMBL8969171 | 0.79 | — | — | |
| SCHEMBL19380983 | 0.79 | — | — | |
| SCHEMBL23488994 | 0.75 | STING1 (0.32) | — | |
| SCHEMBL2761303 | 0.72 | KMT2A (0.39) | — | |
| SCHEMBL2761304 | 0.72 | KMT2A (0.39) | — | |
| SCHEMBL25676269 | 0.72 | STING1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023010134-A1 | PEPTIDE LIGANDS FOR CNS AND OCULAR DELIVERY OF RNAI COMPOUNDS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022147214-A2 | CYCLIC-DISULFIDE MODIFIED PHOSPHATE BASED OLIGONUCLEOTIDE PRODRUGS | ALNYLAM PHARMACEUTICALS, INC. (US) | 2022-07-07 | — | — | WO | disclosed |
| US-10844038-B2 | 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions | SABILA BIOSCIENCES LLC (US) | 2020-11-24 | — | — | US | disclosed |
| US-10844038-B2 | 1,2-dithiolane compounds useful in neuroprotection, autoimmune and cancer diseases and conditions | SABILA BIOSCIENCES LLC (US) | 2020-11-24 | — | — | US | disclosed |
| EP-3509599-A1 | 1,2-DITHIOLANE COMPOUNDS USEFUL IN NEUROPROTECTION, AUTOIMMUNE AND CANCER DISEASES AND CONDITIONS | Sabila Biosciences LLC (US) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018049127-A1 | 1,2-DITHIOLANE COMPOUNDS USEFUL IN NEUROPROTECTION, AUTOIMMUNE AND CANCER DISEASES AND CONDITIONS | SABILA BIOSCIENCES LLC (US) | 2018-03-15 | — | — | WO | disclosed |
| US-6417009-B1 | COUPLING LIPID | AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY INSTITUTE (AU) | 2002-07-09 | — | — | US | disclosed |