Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751164 | 0.83 | TSHR (0.38) | TSHRCHRM4CHRM3SLC6A2SLC6A4 | |
| SCHEMBL27771861 | 0.76 | TSHR (0.38) | TSHRCHRM4CHRM3SLC6A2SLC6A4 | |
| SCHEMBL18533183 | 0.76 | SLC6A2 (0.44) | TSHRCHRM4CHRM3SLC6A2SLC6A4 | |
| SCHEMBL11162550 | 0.71 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL18055938 | 0.71 | SLC6A2 (0.53) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL15481911 | 0.71 | SLC6A2 (0.53) | TSHRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22000936 | 0.69 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13257724 | 0.69 | CYP2D6 (0.52) | TSHRCHRM3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16510079 | 0.69 | CYP2D6 (0.52) | TSHRCHRM3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2743213 | 0.69 | CYP2D6 (0.52) | TSHRCHRM3SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1174971-C | Morpholino ethers | 葛兰素惠尔康有限公司 | 2004-11-10 | — | — | CN | disclosed |
| US-6410528-B1 | FUNGICIDES, ANTIPROTOZOA AGENT | GLAXO WELLCOME S.A. (ES) | 2002-06-25 | — | — | US | disclosed |
| EP-1077959-A1 | MORPHOLINO ETHERS | Glaxo Wellcome S.A. (ES) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058512-A1 | MORPHOLINO ETHERS | GLAXO WELLCOME S.A. (ES) | 1999-11-18 | — | — | WO | disclosed |