SCHEMBL7735878

SCHEMBL7735878

CC(C)(C)OC(=O)N[C@@H]1CCN[C@](C(=O)O)(C(=O)OC(C)(C)C)C1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
BTK Q06187 1/20 0.44
GAA P10253 2/20 0.40
CTSK P43235 2/20 0.39
KDM1A O60341 1/20 0.37
MAOB P27338 1/20 0.37
HSD11B1 P28845 5/20 0.36
EPHX2 P34913 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
KMT2A Q03164 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
EPHX1 P07099 1/20 0.34
ARG1 P05089 1/20 0.34
ARG2 P78540 1/20 0.34
CYP2C9 P11712 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8149726 1.00 BTK (0.44) BTKGAACTSKKDM1AMAOB
SCHEMBL8150637 0.90 BTK (0.41) BTKGAACTSKKDM1AMAOB
SCHEMBL8143603 0.90 BTK (0.41) BTKGAACTSKKDM1AMAOB
SCHEMBL31211275 0.79 BTK (0.46) BTKGAACTSKKDM1AMAOB
SCHEMBL221457 0.79
SCHEMBL21035310 0.78 BTK (0.44) BTKGAACTSKKDM1AMAOB
SCHEMBL31599674 0.78 BTK (0.44) BTKGAACTSKKDM1AMAOB
SCHEMBL8149873 0.77 EPHX1 (0.41) BTKKDM1AMAOBEPHX2KMT2A
SCHEMBL26621674 0.76 BTK (0.46) BTKGAACTSKKDM1AMAOB
SCHEMBL7488055 0.73 CYP4F2 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6399629-B1 PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY MICROCIDE PHARMACEUTICALS, INC. 2002-06-04 US disclosed
WO-2000001714-A1 EFFLUX PUMP INHIBITORS MICROCIDE PHARMACEUTICALS, INC. (US) 2000-01-13 WO disclosed