Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 5/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29757859 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL29481032 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL260266 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL30489007 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL260267 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL6261864 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL30592537 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL260276 | 1.00 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8277375 | 0.87 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL10071834 | 0.87 | MEN1 (0.42) | SLC6A2SLC6A4SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 214 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542961-B1 | TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE FOR USE IN TREATMENT OF CNS DISORDERS | SEPRACOR INC (US) | 2013-09-11 | — | — | EP | claimed |
| JP-2686366-B2 | — | — | 1997-12-08 | — | — | JP | claimed |
| EP-0724552-A1 | PROCESS FOR PREPARING A CHIRAL TETRALONE | PFIZER (US) | 1996-08-07 | — | — | EP | claimed |
| WO-1995015299-A1 | PROCESS FOR PREPARING A CHIRAL TETRALONE | PFIZER INC. (US) | 1995-06-08 | — | — | WO | claimed |
| EP-0295050-B1 | PROCESS FOR PREPARING A 4,4-DIPHENYLBUTANOIC ACID DERIVATIVE | PFIZER INC. (US) | 1991-04-17 | — | — | EP | claimed |
| EP-0341015-A2 | Improved process for preparing a ketimine | PFIZER INC. (US) | 1989-11-08 | — | — | EP | claimed |
| EP-0295050-A1 | Process for preparing a 4,4-diphenylbutanoic acid derivative | PFIZER INC. (US) | 1988-12-14 | — | — | EP | claimed |
| JP-7002718-A | — | — | None | — | — | JP | disclosed |
| JP-7002718-A | — | — | None | — | — | JP | disclosed |
| US-11802274-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2023-10-31 | — | — | US | disclosed |
| US-11802274-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | CODEXIS, INC. (US) | 2023-10-31 | — | — | US | disclosed |
| US-20230295673-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-09-21 | — | — | US | disclosed |
| US-20230295673-A1 | ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2023-09-21 | — | — | US | disclosed |
| WO-1993015059-A1 | 3-PHENYLUREIDO-AZEPIN-2-ONES AND -BENZAZEPIN-2-ONES USEFUL AS CHOLECYSTOKININ ANTAGONISTS | PFIZER INC. (US) | 1993-08-05 | — | — | WO | disclosed |
| WO-1993012062-A1 | PROCESS FOR PREPARING KETONE ENANTIOMER | PFIZER INC. (US) | 1993-06-24 | — | — | WO | disclosed |
| US-5196607-A | Process for preparing ketone enantiomer | PFIZER INC. (US) | 1993-03-23 | — | — | US | disclosed |
| EP-0346226-B1 | PROCESS FOR THE PREPARATION OF 4-ARYL DISUBSTITUTED-1-TETRALONES | SYNTHELABO (FR) | 1993-02-17 | — | — | EP | disclosed |
| US-5019655-A | Method of preparing 4-dichlorophenyl-1-tetralones | DELALANDE S.A. (FR) | 1991-05-28 | — | — | US | disclosed |
| EP-0341015-A2 | Improved process for preparing a ketimine | PFIZER INC. (US) | 1989-11-08 | — | — | EP | disclosed |
| EP-0295050-A1 | Process for preparing a 4,4-diphenylbutanoic acid derivative | PFIZER INC. (US) | 1988-12-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11802274-B2 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds | AKR1C4, AKR7A2, AKR1C2 | SLC6A2 3083/4885SLC6A4 3318/4885SLC6A3 3683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.