Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.68 |
| ▸ | PDE1A | P54750 | 7/20 | 0.68 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.68 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.68 |
| ▸ | PDE2A | O00408 | 1/20 | 0.56 |
| ▸ | PDE9A | O76083 | 1/20 | 0.56 |
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE6C | P51160 | 1/20 | 0.56 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7738215 | 0.99 | PDE5A (0.69) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7740247 | 0.97 | PDE5A (0.70) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7740263 | 0.91 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7740251 | 0.89 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7736985 | 0.88 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7740279 | 0.87 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7738299 | 0.87 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7738272 | 0.87 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CPDE2A | |
| SCHEMBL7731162 | 0.86 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL7737752 | 0.86 | PDE5A (0.68) | PDE5APDE1APDE1BPDE1CPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6683081-B2 | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOPHATE METABOLIZING PHOSPHODIESTERASES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |
| US-6683081-B2 | INHIBITORS OF CYCLIC GUANOSINE 3',5'-MONOPHOPHATE METABOLIZING PHOSPHODIESTERASES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-01-27 | — | — | US | disclosed |