Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.81 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7740429 | 0.92 | KDM4E (0.78) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL6204017 | 0.90 | KDM4E (0.86) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL6204734 | 0.89 | KDM4E (1.00) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL6204768 | 0.87 | KDM4E (0.80) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL18038659 | 0.84 | MAPT (0.93) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL7738707 | 0.83 | POLB (0.70) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL6204810 | 0.83 | POLB (0.88) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL6204972 | 0.82 | POLB (1.00) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL3816203 | 0.81 | KDM4E (0.55) | KDM4EMEN1KMT2APOLBMAPT | |
| SCHEMBL13649612 | 0.81 | KDM4E (0.55) | KDM4EMEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |