Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | HPGD | P15428 | 5/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.72 |
| ▸ | GAA | P10253 | 2/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.72 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.72 |
| ▸ | GLA | P06280 | 1/20 | 0.72 |
| ▸ | AHR | P35869 | 1/20 | 0.72 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.72 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.72 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.72 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.72 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.72 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Transtorine SCHEMBL5144405 | 0.84 | KDM4E (1.00) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| Transtorine SCHEMBL29366068 | 0.84 | KDM4E (1.00) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| Transtorine SCHEMBL29841751 | 0.82 | KDM4E (0.96) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| SCHEMBL3290252 | 0.82 | KDM4E (0.72) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| SCHEMBL57291 | 0.81 | KDM4E (0.66) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| SCHEMBL31243255 | 0.81 | KDM4E (0.66) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| SCHEMBL13545149 | 0.81 | KDM4E (0.66) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| SCHEMBL13543209 | 0.81 | HPGD (0.66) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| Transtorine SCHEMBL30853453 | 0.81 | KDM4E (0.70) | KDM4EHPGDCYP1A2GAAHSD17B10 | |
| SCHEMBL31437284 | 0.78 | KDM4E (0.62) | KDM4EHPGDCYP1A2GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790744-B2 | Cyclic peptide antifungal agents and process for preparation thereof | ELI LILLY AND COMPANY (US) | 2010-09-07 | — | — | US | disclosed |
| US-6743777-B1 | TRISPHENYL ACYL DERIVATIVES OF THE ECHINOCANDIN CLASS; CANDIDA ALBICANS; ANTIFUNGAL AND ANTIPARASITIC; CYCLIC HEXAPEPTIDES HAVING UNIQUE SIDE CHAIN ACYL GROUP | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |