Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.67 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359713 | 0.86 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7363642 | 0.81 | PDE4A (0.87) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL7139813 | 0.81 | PDE4A (0.68) | PDE4APDE4DPDE4CPDE4BMEN1 | |
| SCHEMBL8697092 | 0.80 | PDE4A (0.75) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL6636364 | 0.80 | PDE4A (0.71) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL31427010 | 0.80 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL31427009 | 0.80 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL6637552 | 0.80 | PDE4A (1.00) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| Pyridopyridazinone SCHEMBL7367220 | 0.80 | PDE4A (0.98) | PDE4APDE4DPDE4CPDE4BPDE3B | |
| SCHEMBL8693550 | 0.79 | PDE4A (0.65) | PDE4APDE4DPDE4CPDE4BPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001011933-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A 7-(2-AMINOETHYL)-BENZOTHIAZOLONE AND A PDE4 INHIBITOR | ASTRAZENECA UK LIMITED (GB) | 2001-02-22 | — | — | WO | claimed |
| WO-2001011933-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING A 7-(2-AMINOETHYL)-BENZOTHIAZOLONE AND A PDE4 INHIBITOR | ASTRAZENECA UK LIMITED (GB) | 2001-02-22 | — | — | WO | disclosed |