SCHEMBL7739019

SCHEMBL7739019

CC(=O)Nc1oc(-c2ccccc2-c2ccc([N+](=O)[O-])cc2O)nc1-c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 7/20 0.64
FLT1 P17948 1/20 0.64
FLT4 P35916 1/20 0.64
ABCG2 Q9UNQ0 2/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
HPN P05981 1/20 0.42
CXCR1 P25024 2/20 0.42
CXCR2 P25025 2/20 0.42
ALOX15 P16050 1/20 0.41
ABCB1 P08183 1/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
MYC P01106 1/20 0.40
MAX P61244 1/20 0.40
PPARG P37231 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7744065 0.92 KDR (0.54) KDRFLT1FLT4SMN1; SMN2HPN
SCHEMBL7744645 0.91 KDR (0.55) KDRFLT1FLT4ABCG2SMN1; SMN2
SCHEMBL7739067 0.91 KDR (0.52) KDRFLT1FLT4RAB9ASMN1; SMN2
SCHEMBL7744052 0.90 KDR (0.52) KDRFLT1FLT4ABCG2NPC1
SCHEMBL7744648 0.89 KDR (0.55) KDRFLT1FLT4ABCG2NPC1
SCHEMBL7746566 0.89 FLT1 (0.49) KDRFLT1FLT4ABCG2NPC1
SCHEMBL7739074 0.89 KDR (0.53) KDRFLT1FLT4ABCG2RAB9A
SCHEMBL7746612 0.88 KDR (0.48) KDRFLT1FLT4CXCR1CXCR2
SCHEMBL7744176 0.87 KDR (0.48) KDRFLT1FLT4SMN1; SMN2HPN
SCHEMBL7739018 0.87 KDR (0.62) KDRFLT1FLT4ABCG2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP claimed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP claimed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO claimed
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP disclosed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP disclosed
US-6228871-B1 THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY MERCK & CO., INC. 2001-05-08 US disclosed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO disclosed