Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 7/20 | 0.79 |
| ▸ | SORT1 | Q99523 | 7/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 4-Chloroaniline SCHEMBL7744339 | 0.91 | GRN (0.79) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL3069753 | 0.89 | GRN (1.00) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL7739174 | 0.89 | GRN (0.76) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL7744356 | 0.86 | GRN (0.68) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL1897360 | 0.81 | GRN (0.80) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL1898740 | 0.81 | NPSR1 (0.85) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL893061 | 0.80 | GRN (0.82) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL13219146 | 0.80 | GRN (0.82) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL4689814 | 0.80 | GRN (0.64) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL7744333 | 0.80 | GRN (0.76) | GRNSORT1NPSR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |