Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.71 |
| ▸ | CCNE1 | P24864 | 17/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.71 |
| ▸ | CDK1 | P06493 | 16/20 | 0.69 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.69 |
| ▸ | FLT3 | P36888 | 4/20 | 0.69 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.69 |
| ▸ | CDK4 | P11802 | 3/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.69 |
| ▸ | CCND1 | P24385 | 3/20 | 0.69 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.64 |
| ▸ | CDK7 | P50613 | 1/20 | 0.64 |
| ▸ | CDK9 | P50750 | 1/20 | 0.64 |
| ▸ | CCNH | P51946 | 1/20 | 0.64 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739727 | 1.00 | CDK2 (0.71) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| Hydrochloric Acid SCHEMBL6821662 | 0.99 | CDK2 (0.70) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| Hydrochloric Acid SCHEMBL6821665 | 0.99 | CDK2 (0.70) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| Hydrochloric Acid SCHEMBL6821007 | 0.90 | CDK2 (0.81) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| Hydrochloric Acid SCHEMBL6821008 | 0.90 | CDK2 (0.81) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| SCHEMBL6942289 | 0.89 | CDK2 (0.66) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| SCHEMBL6942284 | 0.89 | CDK2 (0.66) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| Hydrochloric Acid SCHEMBL6944431 | 0.88 | CCNE1 (0.65) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| Hydrochloric Acid SCHEMBL6944436 | 0.88 | CCNE1 (0.65) | CDK2CCNE1PDGFRACDK1CCNE2 | |
| SCHEMBL27570965 | 0.86 | CDK2 (0.77) | CDK2CCNE1PDGFRACDK1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413974-B1 | INHIBITORS OF CYCLIN DEPENDENT KINASES, PARTICULARLY CDK-2; PREVENTING APOPTOSIS IN NEURONAL CELLS; ANTINEOPLASTIC AGENTS; NEURONAL INJURY AND DEGENERATION; CEREBROVASCULAR DISEASE | AVENTIS PHARMACEUTICALS INC. | 2002-07-02 | — | — | US | disclosed |