Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 3/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450002 | 0.88 | MAPK11 (0.53) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5258115 | 0.88 | MAPK14 (0.52) | MAPK11MAPK14MAPK13MAPK12HTR1A | |
| SCHEMBL5447921 | 0.88 | MAPK11 (0.67) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| Water SCHEMBL6221859 | 0.87 | MAPK11 (0.52) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5446579 | 0.85 | MAPK11 (0.67) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL14519687 | 0.80 | MAPK11 (0.54) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5255649 | 0.79 | MAPK11 (0.76) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| Hydrochloric Acid SCHEMBL5259493 | 0.78 | MAPK11 (0.74) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5452540 | 0.78 | MAPK11 (0.66) | LSSMAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5448062 | 0.77 | MAPK14 (0.50) | MAPK11MAPK14MAPK13MAPK12HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423713-B1 | Substituted pyrazoles as p38 kinase inhibitors | G. D. SEARLE & COMPANY | 2002-07-23 | — | — | US | disclosed |
| CN-1342157-A | Substituted pyrazoles ASP38 kinase inhibitors | SEARLE & CO (US) | 2002-03-27 | — | — | CN | disclosed |