Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6286833 | 1.00 | TP53 (0.51) | TP53MEN1KMT2ATNFPDE4A | |
| SCHEMBL6281609 | 1.00 | TP53 (0.51) | TP53MEN1KMT2ATNFPDE4A | |
| SCHEMBL4858305 | 0.84 | TNF (0.60) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6287394 | 0.84 | TNF (0.60) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6281501 | 0.84 | TNF (0.60) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4856275 | 0.84 | TP53 (0.60) | TP53MEN1KMT2ATNFPDE4A | |
| SCHEMBL6289218 | 0.84 | TP53 (0.60) | TP53MEN1KMT2ATNFPDE4A | |
| SCHEMBL6287582 | 0.84 | TP53 (0.60) | TP53MEN1KMT2ATNFPDE4A | |
| SCHEMBL4857855 | 0.83 | TP53 (0.56) | TP53MEN1KMT2ATNFPDE4A | |
| SCHEMBL6286610 | 0.83 | TP53 (0.56) | TP53MEN1KMT2ATNFPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6429221-B1 | INHIBITORS OF TUMOR NECROSIS FACTOR; USED TO TREAT CACHEXIA, ENDOTOXIC SHOCK, AND RETROVIRUS REPLICATION | CELGENE CORPORATION | 2002-08-06 | — | — | US | claimed |