Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.63 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.45 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13646020 | 0.91 | PNP (0.63) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL11949491 | 0.91 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL6848324 | 0.91 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL15459906 | 0.91 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL7111379 | 0.91 | PNP (0.76) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL17752037 | 0.88 | PNP (0.60) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL23547685 | 0.82 | POLB (0.63) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL30930806 | 0.82 | POLB (0.63) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL25619590 | 0.82 | PNP (0.52) | PNPLMNATP53HTTPDE4D | |
| SCHEMBL25619505 | 0.82 | PNP (0.52) | PNPLMNATP53HTTPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929218-A4 | P2Y RECEPTOR ANTAGONISTS | UNIV NORTH CAROLINA (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-0929218-A2 | P2Y RECEPTOR ANTAGONISTS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998018430-A2 | P2Y RECEPTOR ANTAGONISTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-05-07 | — | — | WO | disclosed |