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Triaziquone

Triaziquone

SCHEMBL7743549

N#Cc1ccc(Cn2cncc2CN2CCc3ccc(N)cc3C2)cc1.O=C(O)C(F)(F)F.O=C1C=C(N2CC2)C(=O)C(N2CC2)=C1N1CC1

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ FNTA P49354 20/20 0.45
▸ FNTB P49356 20/20 0.45
▸ PGGT1B P53609 11/20 0.45
▸ NRAS P01111 1/20 0.43
▸ HRAS P01112 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tromethamine SCHEMBL8483614 0.79 FNTA (0.50) FNTAFNTBPGGT1BNRASHRAS
Trichloroethylene SCHEMBL7744216 0.79 FNTA (0.51) FNTAFNTBPGGT1BNRASHRAS
SCHEMBL7744226 0.72 FNTA (0.54) FNTAFNTBPGGT1BNRASHRAS
SCHEMBL7738283 0.72 FNTA (0.54) FNTAFNTBPGGT1BNRASHRAS
SCHEMBL7743534 0.71 FNTA (0.58) FNTAFNTBPGGT1BNRASHRAS
SCHEMBL8487144 0.71 PRKAA2 (0.53) FNTAFNTBPGGT1BNRASHRAS
SCHEMBL7743768 0.71 FNTA (0.66) FNTAFNTBPGGT1BNRASHRAS
SCHEMBL7746075 0.70 FNTA (0.52) FNTAFNTBPGGT1BNRASHRAS
Hydrochloric Acid SCHEMBL7738189 0.70 FNTA (0.64) FNTAFNTBPGGT1BNRASHRAS
Trifluoroacetic Acid SCHEMBL7484732 0.69 CYP11B1 (0.61) FNTAFNTBPGGT1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1045843-A4 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2001-10-24 — — EP disclosed
EP-1045843-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2000-10-25 — — EP disclosed
US-5977134-A Inhibitors of farnesyl-protein transferase MERCK & CO., INC. (US) 1999-11-02 — — US disclosed
WO-1999028313-A1 INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 1999-06-10 — — WO disclosed