Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BRS3 | P32247 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.40 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742356 | 0.86 | TACR1 (0.58) | TACR1BCHEACHEBRS3CALCRL | |
| SCHEMBL7745636 | 0.86 | TACR1 (0.51) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7742400 | 0.85 | TACR1 (0.52) | TACR1BRS3KMT2ASSTR2 | |
| SCHEMBL7743621 | 0.84 | TACR1 (0.52) | TACR1MEN1KMT2ASMN1; SMN2SSTR2 | |
| SCHEMBL7737704 | 0.80 | TACR1 (0.58) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7745643 | 0.79 | TACR1 (0.59) | TACR1BCHEBRS3CALCRL | |
| SCHEMBL7737625 | 0.79 | BRS3 (0.60) | TACR1BRS3CALCRL | |
| SCHEMBL7742495 | 0.78 | SSTR2 (0.51) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7743652 | 0.78 | SSTR2 (0.47) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7743607 | 0.78 | TACR1 (0.59) | TACR1BRS3CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | claimed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | claimed |
| WO-1997006803-A1 | 2-ACYLAMINOPROPANAMIDES AS GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | claimed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | claimed |