SCHEMBL7744059

SCHEMBL7744059

O=C(Nc1oc(-c2ccc(-c3ccccc3)cc2O)nc1-c1cccc(Cl)c1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 3/20 0.53
FLT1 P17948 1/20 0.48
FLT4 P35916 1/20 0.48
GRM5 P41594 1/20 0.47
ADORA1 P30542 2/20 0.46
ADORA2A P29274 1/20 0.46
SERPINE1 P05121 2/20 0.46
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC2 Q92769 1/20 0.44
SUCNR1 Q9BXA5 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
MAPT P10636 1/20 0.42
TDP2 O95551 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
KDM4E B2RXH2 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7985537 0.92 KDR (0.53) KDRFLT1FLT4ADORA1ADORA2A
SCHEMBL7746598 0.90 KDR (0.58) KDRFLT1FLT4ADORA1HDAC1
SCHEMBL7744650 0.90 HDAC2 (0.48) KDRFLT1FLT4HDAC2RAB9A
SCHEMBL7739078 0.89 KDR (0.68) KDRFLT1FLT4GRM5HSP90AA1
SCHEMBL7739068 0.89 KDR (0.47) KDRFLT1FLT4ADORA1ADORA2A
SCHEMBL7746649 0.87 KDR (0.47) KDRFLT1FLT4SERPINE1HDAC1
SCHEMBL7738993 0.85 KDR (0.55) KDRFLT1FLT4HSP90AA1HSP90AB1
SCHEMBL7744061 0.85 KDR (0.50) KDRFLT1FLT4ADORA1ADORA2A
SCHEMBL7744167 0.84 HDAC1 (0.53) KDRFLT1FLT4HDAC1HDAC2
SCHEMBL7744086 0.84 KDR (0.51) KDRFLT1FLT4HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP claimed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP claimed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO claimed
EP-1097147-A4 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO INC (US) 2001-11-21 EP disclosed
EP-1097147-A1 NOVEL ANGIOGENESIS INHIBITORS Merck & Co., Inc. (US) 2001-05-09 EP disclosed
US-6228871-B1 THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY MERCK & CO., INC. 2001-05-08 US disclosed
WO-2000002871-A1 NOVEL ANGIOGENESIS INHIBITORS MERCK & CO., INC. (US) 2000-01-20 WO disclosed