Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 10/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 3/20 | 0.46 |
| ▸ | FNTB | P49356 | 3/20 | 0.46 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8480536 | 0.84 | CYP11B1 (0.56) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL7744245 | 0.83 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7738190 | 0.82 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL8486896 | 0.78 | IDO1 (0.55) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7744190 | 0.75 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL14193110 | 0.75 | CYP11B1 (0.46) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL10588300 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL8484191 | 0.74 | CYP11B1 (0.58) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL5891719 | 0.73 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1FNTAFNTB | |
| SCHEMBL7083825 | 0.73 | CYP11B1 (0.76) | CYP11B1CYP11B2CYP19A1FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | claimed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | claimed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |