Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.54 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 9/20 | 0.41 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.40 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.40 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | BHMT | Q93088 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL8487870 | 0.93 | SLC7A5 (0.62) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL1163213 | 0.93 | SLC7A5 (0.62) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL8487875 | 0.93 | SLC7A5 (0.62) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL8712670 | 0.93 | SLC7A5 (0.62) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL8712672 | 0.93 | SLC7A5 (0.62) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Isoleucine SCHEMBL386322 | 0.91 | SLC7A5 (0.44) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL26919279 | 0.89 | GSR (0.49) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL8892693 | 0.89 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Asparagine SCHEMBL8892690 | 0.89 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 | |
| Aspartic Acid SCHEMBL27476210 | 0.89 | SLC7A5 (0.58) | SLC7A5SLC1A3SLC1A2SLC1A1GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6428967-B1 | DETECTING A STRESS THAT ALTERS A FUNCTIONAL INTERACTION OF AN LOW DENSITY LIPOPROTEIN (LDL) RECEPTOR BINDING POLYPEPTIDE WITH AN LDL RECEPTOR INTERACTION DOMAIN | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2002-08-06 | — | — | US | disclosed |