Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 5/20 | 0.63 |
| ▸ | SORT1 | Q99523 | 5/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1897360 | 0.86 | GRN (0.80) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL3069753 | 0.78 | GRN (1.00) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL19691155 | 0.77 | MEN1 (0.66) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL893061 | 0.75 | GRN (0.82) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL13219146 | 0.75 | GRN (0.82) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL25346695 | 0.74 | GRN (0.72) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL7739174 | 0.74 | GRN (0.76) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL7744333 | 0.74 | GRN (0.76) | GRNSORT1NPSR1GAAMAPT | |
| SCHEMBL574266 | 0.73 | NPC1 (0.60) | GRNSORT1MAPTALDH1A1NPC1 | |
| SCHEMBL7739178 | 0.72 | GRN (0.79) | GRNSORT1NPSR1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | claimed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | claimed |
| EP-1252156-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | University College London (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057024-A1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UNIVERSITY COLLEGE LONDON (GB) | 2001-08-09 | — | — | WO | disclosed |