Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19292680 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| SCHEMBL22536533 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| SCHEMBL1706921 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| SCHEMBL199035 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| SCHEMBL931868 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| SCHEMBL199034 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| SCHEMBL3190846 | 0.78 | HRH3 (0.54) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| Hydrochloric Acid SCHEMBL7375375 | 0.77 | GRIK1 (0.53) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| Hydrochloric Acid SCHEMBL15718411 | 0.77 | GRIK1 (0.53) | ARG1CYP1A2ALOX15CYP2C19GRIK1 | |
| Hydrochloric Acid SCHEMBL7375374 | 0.77 | GRIK1 (0.53) | ARG1CYP1A2ALOX15CYP2C19GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313159-B1 | FOR THERAPY OF GLUTAMATE MEDIATED DISEASE, DISORDER SUCH AS: STROKE, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, HUNTINGTON'S DISEASE, SCHIZOPHRENIA, ISCHEMIA, PAIN, DIABETIC NEUROPATHY, TRAUMA, NERVOUS INSULT | GUILFORD PHARMACEUTICALS INC. | 2001-11-06 | — | — | US | claimed |
| WO-2001014390-A2 | METABOTROPIC GLUTAMATE RECEPTOR LIGAND DERIVATIVES AS NAALADase INHIBITORS | GUILFORD PHARMACEUTICALS (US) | 2001-03-01 | — | — | WO | claimed |