Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.69 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.69 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745329 | 1.00 | SRD5A2 (0.69) | SRD5A2SRD5A1ARCYP17A1KDM4E | |
| SCHEMBL8074664 | 0.88 | SRD5A2 (0.69) | SRD5A2SRD5A1AR | |
| SCHEMBL8074665 | 0.88 | SRD5A2 (0.69) | SRD5A2SRD5A1AR | |
| SCHEMBL8063981 | 0.85 | SRD5A2 (0.75) | SRD5A2SRD5A1 | |
| SCHEMBL8063986 | 0.85 | SRD5A2 (0.75) | SRD5A2SRD5A1 | |
| SCHEMBL7382153 | 0.82 | SRD5A2 (0.71) | SRD5A2SRD5A1CYP17A1KDM4EMAPT | |
| SCHEMBL7382151 | 0.82 | SRD5A2 (0.71) | SRD5A2SRD5A1CYP17A1KDM4EMAPT | |
| SCHEMBL4269548 | 0.82 | SRD5A2 (0.64) | SRD5A2SRD5A1AR | |
| SCHEMBL4269554 | 0.82 | SRD5A2 (0.64) | SRD5A2SRD5A1AR | |
| SCHEMBL5682764 | 0.82 | SRD5A2 (0.64) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649306-B1 | ESTER DERIVATIVES OF 4-AZA-STEROIDS | MERCK & CO INC (US) | 2001-01-10 | — | — | EP | disclosed |
| US-5693809-A | PREGNANES FOR TREATING ALOPECIA, ACNE AND SKIN DISORDER | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| US-5610162-A | ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1997-03-11 | — | — | US | disclosed |
| EP-0649306-A4 | ESTER DERIVATIVES OF 4-AZA-STEROIDS. | MERCK & CO INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0649306-A1 | ESTER DERIVATIVES OF 4-AZA-STEROIDS | MERCK & CO. INC. (US) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993023041-A1 | ESTER DERIVATIVES OF 4-AZA-STEROIDS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023039-A1 | SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |