Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 8/20 | 0.62 |
| ▸ | BRS3 | P32247 | 2/20 | 0.59 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.56 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.56 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.55 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.55 |
| ▸ | ITGAL | P20701 | 3/20 | 0.55 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742348 | 0.93 | TACR1 (0.61) | TACR1BRS3ERAP2ITGB2ICAM1 | |
| SCHEMBL8816212 | 0.92 | TACR1 (0.61) | TACR1BRS3CALCRL | |
| SCHEMBL7745643 | 0.86 | TACR1 (0.59) | TACR1BRS3CALCRL | |
| SCHEMBL7743082 | 0.85 | TACR1 (0.66) | TACR1BRS3CALCRL | |
| SCHEMBL7742356 | 0.85 | TACR1 (0.58) | TACR1BRS3CALCRL | |
| SCHEMBL7737625 | 0.85 | BRS3 (0.60) | TACR1BRS3CALCRL | |
| SCHEMBL7743791 | 0.85 | TACR1 (0.62) | TACR1BRS3CALCRL | |
| SCHEMBL8813966 | 0.84 | TACR1 (0.60) | TACR1BRS3CALCRLTP53 | |
| SCHEMBL8748599 | 0.84 | TACR1 (0.59) | TACR1BRS3CALCRL | |
| SCHEMBL7743112 | 0.84 | TACR1 (0.59) | TACR1BRS3CALCRL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | disclosed |
| EP-0761220-A1 | 2-Acylaminopropanamides as growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |
| WO-1997006803-A1 | 2-ACYLAMINOPROPANAMIDES AS GROWTH HORMONE SECRETAGOGUES | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |
| US-5565568-A | USEFUL IN TREATMENT OR PREVENTION OF A PHYSIOLOGICAL DISORDER ASSOCIATED WITH AN EXCESS OF TACHYKININS | ELI LILLY AND COMPANY (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |