Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 9/20 | 0.61 |
| ▸ | BRS3 | P32247 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 5/20 | 0.53 |
| ▸ | MMP8 | P22894 | 4/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.53 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.53 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742348 | 0.90 | TACR1 (0.61) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8813966 | 0.89 | TACR1 (0.60) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7745651 | 0.88 | TACR1 (0.58) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7737704 | 0.88 | TACR1 (0.58) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7745566 | 0.88 | BRS3 (0.58) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7743760 | 0.86 | BRS3 (0.56) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7737679 | 0.86 | TACR1 (0.68) | TACR1BRS3 | |
| SCHEMBL7742413 | 0.86 | BRS3 (0.56) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7737651 | 0.86 | BRS3 (0.56) | TACR1BRS3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7743754 | 0.86 | TACR1 (0.58) | TACR1BRS3MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819005-A4 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2001-03-21 | — | — | EP | disclosed |
| EP-0819005-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031214-A1 | 2-ACYLAMINOPROPANAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-10-10 | — | — | WO | disclosed |