Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 5/20 | 0.82 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.55 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23447713 | 0.91 | P2RX1 (1.00) | P2RX1NPC1RAB9ATRPA1CYP1A2 | |
| SCHEMBL30455592 | 0.85 | NPC1 (0.74) | P2RX1NPC1RAB9AKCNK3HPGD | |
| SCHEMBL683803 | 0.85 | PTGS1 (0.68) | P2RX1NPC1RAB9ATRPA1CYP1A2 | |
| SCHEMBL26095994 | 0.85 | P2RX1 (0.64) | P2RX1KCNK3LMNAMAPTRXFP1 | |
| SCHEMBL6054935 | 0.84 | MEN1 (0.73) | P2RX1TRPA1KCNK3LMNARXFP1 | |
| SCHEMBL25777244 | 0.84 | P2RX1 (0.80) | P2RX1NPC1RAB9ATRPA1CYP1A2 | |
| SCHEMBL5668018 | 0.84 | P2RX1 (0.80) | P2RX1NPC1RAB9ATRPA1CYP1A2 | |
| SCHEMBL30554615 | 0.83 | P2RX1 (0.65) | P2RX1TRPA1MAPTRXFP1P2RX4 | |
| SCHEMBL3246188 | 0.83 | P2RX1 (0.65) | P2RX1TRPA1MAPTRXFP1P2RX4 | |
| SCHEMBL3028317 | 0.83 | P2RX1 (0.61) | P2RX1TRPA1CYP1A2KCNK3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |