Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.69 |
| ▸ | FLT1 | P17948 | 7/20 | 0.69 |
| ▸ | KIT | P10721 | 2/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.69 |
| ▸ | FLT4 | P35916 | 1/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 7/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4978394 | 0.90 | KDR (0.74) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4981324 | 0.88 | KDR (0.84) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4981221 | 0.84 | KDR (0.80) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4979990 | 0.82 | KDR (0.71) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4981328 | 0.82 | KDR (0.71) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4980207 | 0.82 | KDR (0.77) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4976103 | 0.82 | KDR (1.00) | KDRFLT1KITABL1EGFR | |
| SCHEMBL29356168 | 0.82 | KDR (1.00) | KDRFLT1KITABL1EGFR | |
| SCHEMBL4982066 | 0.81 | KDR (0.76) | KDRFLT1KITABL1EGFR | |
| SCHEMBL1009579 | 0.81 | KDR (0.70) | KDRFLT1KITABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129075-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000027820-A1 | N-ARYL(THIO)ANTHRANILIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS VEGF RECEPTOR TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2000-05-18 | — | — | WO | disclosed |