Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7743425 | 0.85 | FNTA (0.37) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL7746101 | 0.82 | CYP19A1 (0.43) | CYP19A1HRH3 | |
| SCHEMBL7738290 | 0.81 | CYP19A1 (0.38) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL7743523 | 0.80 | HRH3 (0.40) | CYP19A1HRH3FNTAFNTBCYP11B1 | |
| SCHEMBL7738285 | 0.80 | HRH3 (0.37) | CYP19A1HRH3CYP11B1CYP11B2 | |
| SCHEMBL7744150 | 0.80 | HRH3 (0.37) | CYP19A1HRH3CYP11B1CYP11B2 | |
| SCHEMBL7744111 | 0.80 | HRH3 (0.37) | CYP19A1HRH3CYP11B1CYP11B2 | |
| SCHEMBL7855272 | 0.79 | HRH3 (0.38) | CYP19A1HRH3CYP11B1CYP11B2 | |
| SCHEMBL7743502 | 0.79 | MAPT (0.43) | CYP19A1HRH3 | |
| SCHEMBL3500207 | 0.78 | FNTA (0.43) | CYP19A1HRH3FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | claimed |
| EP-1045843-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-10-24 | — | — | EP | disclosed |
| EP-1045843-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-10-25 | — | — | EP | disclosed |
| US-5977134-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-11-02 | — | — | US | disclosed |
| WO-1999028313-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |