Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.71 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.71 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | TNF | P01375 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9949593 | 0.96 | TNF (0.70) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL476983 | 0.93 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL717039 | 0.93 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL5941456 | 0.93 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL29840774 | 0.93 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL825731 | 0.92 | TNF (0.66) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL6099978 | 0.92 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL825454 | 0.92 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL825982 | 0.92 | TNF (0.60) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL8436482 | 0.91 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200987-B1 | ADMINISTERING AS TUMOR NECROSIS FACTOR INHIBITORS; CACHEXIA, ENDOTOXIN SHOCK; RETROVIRUS VIRICIDES | CELGENE CORPORATION | 2001-03-13 | — | — | US | disclosed |
| US-6075041-A | TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 2000-06-13 | — | — | US | disclosed |
| US-5877200-A | Cyclic amides | CELGENE CORPORATION (US) | 1999-03-02 | — | — | US | disclosed |
| US-5698579-A | INHIBITOR OF TUMOR NECROSIS FACTOR | CELGENE CORPORATION (US) | 1997-12-16 | — | — | US | disclosed |