Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.70 |
| ▸ | MAPT | P10636 | 8/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.70 |
| ▸ | HTT | P42858 | 5/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.70 |
| ▸ | RECQL | P46063 | 2/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7748708 | 1.00 | KDM4E (0.70) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL9458185 | 0.88 | KDM4E (0.74) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL7743078 | 0.87 | MEN1 (0.59) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL7743079 | 0.87 | MEN1 (0.59) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL28223411 | 0.86 | KDM4E (0.70) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL7748683 | 0.86 | KDM4E (0.70) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL7748688 | 0.86 | KDM4E (0.70) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| Hydrochloric Acid SCHEMBL17560786 | 0.85 | MEN1 (0.58) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| SCHEMBL13673522 | 0.84 | KDM4E (0.68) | KDM4EMAPTSMN1; SMN2HTTNPC1 | |
| Hydrochloric Acid SCHEMBL5702983 | 0.84 | KDM4E (0.68) | KDM4EMAPTSMN1; SMN2HTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001025192-A1 | GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE | MELACURE THERAPEUTICS AB (SE) | 2001-04-12 | — | — | WO | claimed |
| WO-2001025192-A1 | GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE | MELACURE THERAPEUTICS AB (SE) | 2001-04-12 | — | — | WO | disclosed |