Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 9/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | HTT | P42858 | 5/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | PHGDH | O43175 | 2/20 | 0.61 |
| ▸ | CCR6 | P51684 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520466 | 1.00 | KDM4E (0.64) | KDM4EMAPTALDH1A1GAAMEN1 | |
| Water SCHEMBL6576230 | 0.99 | KDM4E (0.62) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL9458239 | 0.89 | KDM4E (0.67) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL31530751 | 0.88 | KDM4E (0.69) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13673500 | 0.85 | HTT (0.56) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13673668 | 0.85 | KDM4E (0.62) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13673665 | 0.85 | KDM4E (0.62) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13673670 | 0.85 | KDM4E (0.66) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL13673499 | 0.85 | HTT (0.56) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL15457450 | 0.85 | MEN1 (0.77) | KDM4EMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001025192-A1 | GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE | MELACURE THERAPEUTICS AB (SE) | 2001-04-12 | — | — | WO | claimed |
| WO-2001025192-A1 | GUANIDINE DERIVATIVES AND THEIR USE IN THE PRODUCTION OF A MEDICAMENT FOR BLOCKING XANTHINE OXIDASE/DEHYDROGENASE | MELACURE THERAPEUTICS AB (SE) | 2001-04-12 | — | — | WO | disclosed |